Academic pharmacist Nataly Martini highlights the importance of understanding non-Hodgkin lymphoma and pharmacists’ roles in managing this condition
Friday 1 November 2024, 01:00 AM
14 minutes to Read
Turmeric’s golden glow on a range of chronic ailments
Friday 1 April 2022, 01:00 AM
[Image: iStock.com – alicjane]
Medical herbalist and pharmacist Phil Rasmussen reviews the literature on curcumin, a popular ingredient in natural remedies
The root of turmeric (Curcuma longa or C. domestica) has been used since ancient times as a spice in foods, and in traditional medicine. Widely cultiv
References
- Dei Cas M, Ghidoni R. Dietary curcumin: Correlation between bioavailability and health potential. Nutrients 2019;11(9):2147.
- Abd El-Hack ME, El-Saadony MT, Swelum AA, et al. Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability. J Sci Food Agric 2021;101(14):5747–62.
- Sohn SI, Priya A, Balasubramaniam B, et al. Biomedical applications and bioavailability of curcumin-An updated overview. Pharmaceutics 2021;13(12):2102.
- Gupta NK, Dixit VK. Bioavailability enhancement of curcumin by complexation with phosphatidyl choline. J Pharm Sci 2011;100(5):1987–95.
- Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64(4):353–56.
- Nelson KM, Dahlin JL, Bisson J, et al. The essential medicinal chemistry of curcumin. J Med Chem 2017;60(5):1620–37.
- Zeng L, Yu G, Hao W, et al. The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. Biosci Rep 2021;41(6):BSR20210817.
- Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clin Interv Aging 2014;9:451–58.
- Dai W, Yan W, Leng X, et al. Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. Phytother Res 2021;35(11):5921–35.
- Paultre K, Cade W, Hernandez D, et al. Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review. BMJ Open Sport Exerc Med 2021;7(1):e000935.
- Singhal S, Hasan N, Nirmal K, et al. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials 2021;22(1):105.
- Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res 2012;26(11):1719–25.
- Pourhabibi-Zarandi F, Shojaei-Zarghani S, Rafraf M. Curcumin and rheumatoid arthritis: A systematic review of literature. Int J Clin Pract 2021;75(10):e14280.
- Jennings MR, Parks RJ. Curcumin as an antiviral agent. Viruses 2020;12:1242.
- Anggakusuma Colpitts CC, Schang LM, Rachmawati H, et al. Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut 2014;63:1137.
- Bormann M, Alt M, Schipper L, et al. Turmeric root and its bioactive ingredient curcumin effectively neutralize SARS-CoV-2 in vitro. Viruses 2021;13(10):1914.
- Ardebili A, Pouriayevali MH, Aleshikh S, et al. Antiviral therapeutic potential of curcumin: An update. Molecules 2021;26(22):6994.
- Tripathy S, Verma DK, Thakur M, et al. Curcumin extraction, isolation, quantification and its application in functional foods: A review with a focus on immune enhancement activities and COVID-19. Front Nutr 2021;8:747956.
- Pawar KS, Mastud RN, Pawar SK, et al. Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19: A randomized clinical trial. Front Pharmacol 2021;12:669362.
- Jin T, Song Z, Weng J, et al. Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity. Am J Physiol Endocrinol Metab 2018;314(3):E201–05.
- Pivari F, Mingione A, Brasacchio C, et al. Curcumin and type 2 diabetes mellitus: Prevention and treatment. Nutrients 2019;11(8):1837.
- Uchio R, Kawasaki K, Okuda-Hanafusa C, et al. Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial. Nutr J 2021;20(1):91.
- Mahdavi A, Moradi S, Askari G, et al. Effect of curcumin on glycemic control in patients with type 2 diabetes: A systematic review of randomized clinical trials. Adv Exp Med Biol 2021;1291:139–49.
- Yuan F, Wu W, Ma L, et al. Turmeric and curcuminiods ameliorate disorders of glycometabolism among subjects with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 2022;177:106121.
- Altobelli E, Angeletti PM, Marziliano C, et al. Potential therapeutic effects of curcumin on glycemic and lipid profile in uncomplicated type 2 diabetes-A meta-analysis of randomized controlled trial. Nutrients 2021;13(2):404.
- Zhang HA, Kitts DD. Turmeric and its bioactive constituents trigger cell signaling mechanisms that protect against diabetes and cardiovascular diseases. Mol Cell Biochem 2021;476(10):3785–814.
- Cox FF, Misiou A, Vierkant A, et al. Protective effects of curcumin in cardiovascular diseases-impact on oxidative stress and mitochondria. Cells 2022;11(3):342.
- Qin S, Huang L, Gong J, et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J 2017;16(1):68.
- Yuan F, Dong H, Gong J, et al. A systematic review and meta-analysis of randomized controlled trials on the effects of turmeric and curcuminoids on blood lipids in adults with metabolic diseases. Adv Nutr 2019;10(5):791–802.
- Karandish M, Mozaffari-Khosravi H, Mohammadi SM, et al. Curcumin and zinc co-supplementation along with a loss-weight diet can improve lipid profiles in subjects with prediabetes: a multi-arm, parallel-group, randomized, double-blind placebo-controlled phase 2 clinical trial. Diabetol Metab Syndr 2022;14(1):22.
- Li M, Yue GG, Luo L, et al. Turmeric is therapeutic in vivo on patient-derived colorectal cancer xenografts: Inhibition of growth, metastasis, and tumor recurrence. Front Oncol 2021;10:574827.
- Nocito MC, De Luca A, Prestia F, et al. Antitumoral activities of curcumin and recent advances to improve its oral bioavailability. Biomedicines 2021;9(10):1476.
- Zoi V, Galani V, Lianos GD, et al. The role of curcumin in cancer treatment. Biomedicines 2021;9(9):1086.
- Kumar P, Sulakhiya K, Barua CC, et al. TNF-α, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats. Mol Cell Biochem 2017;431:113–22.
- Zhang Q, Wu L. In vitro and in vivo cardioprotective effects of curcumin against doxorubicin-induced cardiotoxicity: A systematic review. J Oncol 2022;2022:7277562.
- Adiwidjaja J, McLachlan AJ, Boddy AV. Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions. Expert Opin Drug Metab Toxicol 2017;13(9):953–72.
- Vadhan-Raj SV, Weber DM, Wang M, et al. Curcumin downregulates NF-kB and related genes in patients with multiple myeloma: Results of a phase I/II study. Blood 2007;110:1177.
- Bayet-Robert M, Kwiatkowski F, Leheurteur M, et al. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther 2010;9:8–14.
- Bhat A, Mahalakshmi AM, Ray B, et al. Benefits of curcumin in brain disorders. Biofactors 2019;45(5):666–89.
- Gagliardi S, Morasso C, Stivaktakis P, et al. Curcumin formulations and trials: What's new in neurological diseases. Molecules 2020;25(22):5389.
- Scazzocchio B, Minghetti L, D'Archivio M. Interaction between gut microbiota and curcumin: A new key of understanding for the health effects of curcumin. Nutrients 2020;12(9):2499.
- Turmeric. In Drugs and Lactation Database (LactMed) [Internet]. Bethesda, MD: National Library of Medicine (US); 2006–. 18 October 2021. https://www.ncbi.nlm.nih.gov/books/NBK501846/
- Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res 2018;32(6):985–95.
- Bahramsoltani R, Rahimi R, Farzaei MH. Pharmacokinetic interactions of curcuminoids with conventional drugs: A review. J Ethnopharmacol 2017;209:1–12.
- Liu AC, Zhao LX, Lou HX. Curcumin alters the pharmacokinetics of warfarin and clopidogrel in Wistar rats but has no effect on anticoagulation or antiplatelet aggregation. Planta Med 2013;79:971–77.
Class
Hosted Content 2
Chemist Warehouse is sponsoring the Young Pharmacist of the Year Award in the 2025 New Zealand Primary Healthcare Awards | He Tohu Mauri Ora. The Chemist Warehouse leadership team explains what it means to be a Stellar Supporter
Thursday 20 February 2025, 08:03 AM
1 minute to Read
Latest issue
