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Propolis: A powerhouse defence against bugs and inflammation
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Propolis, a bee-derived compound, is gaining greater attention for its effective anti-inflammatory and anti-microbial properties, writes Phil Rasmussen, a pharmacist and medical herbalist
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Sforcin JM. Propolis and the immune system: a review. J Ethnopharmacol 2007;113(1):1–14.
-
Al-Hariri M. Immune's-boosting agent: Immunomodulation potentials of propolis. J Family Community Med 2019;26(1):57–60.
-
Schnitzler P, Neuner A, Nolkemper S, et al. Antiviral activity and mode of action of propolis extracts and selected compounds. Phytother Res 2010;24 Suppl 1:S20–28.
-
Soroy L, Bagus S, Yongkie IP, et al. The effect of a unique propolis compound (Propoelix™) on clinical outcomes in patients with dengue hemorrhagic fever. Infect Drug Resist 2014;7:323–29.
-
Shimizu T, Hino A, Tsutsumi A, et al. Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. Antivir Chem Chemother 2008;19(1):7–13.
-
Mojarab S, Shahbazzadeh D, Moghbeli M, et al. Immune responses to HIV-1 polytope vaccine candidate formulated in aqueous and alcoholic extracts of Propolis: Comparable immune responses to Alum and Freund adjuvants. Microb Pathog 2020;140:103932.
-
Refaat H, Mady FM, Sarhan HA, et al. Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19. Int J Pharm 2021;592:120028.
-
Berretta AA, Silveira MAD, Cóndor Capcha JM, et al. Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Biomed Pharmacother 2020;131:110622.
-
Bachevski D, Damevska K, Simeonovski V, et al. Back to the basics: Propolis and COVID-19. Dermatol Ther 2020;33(4):e13780.
-
Miryan M, Soleimani D, Dehghani L, et al. The effect of propolis supplementation on clinical symptoms in patients with coronavirus (COVID-19): A structured summary of a study protocol for a randomised controlled trial. Trials 2020;21(1):996.
-
Silveira MAD, De Jong D, Berretta AA, et al. Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial. Biomed Pharmacother 2021;138:111526.
-
Sahlan M, Irdiani R, Flamandita D, et al. Molecular interaction analysis of Sulawesi propolis compounds with SARS-CoV-2 main protease as preliminary study for COVID-19 drug discovery. J King Saud Univ Sci 2021;33(1):101234.
-
Khayrani AC, Irdiani R, Aditama R, et al. Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study. J King Saud Univ Sci 2021;33(2):101297.
-
Ali AM, Kunugi H. Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies. Molecules 2021;26(5):1232.
-
Braakhuis A. Evidence on the Health Benefits of Supplemental Propolis. Nutrients 2019;11(11):2705.
-
Jalali M, Ranjbar T, Mosallanezhad Z, et al. Effect of Propolis Intake on Serum C-Reactive Protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) Levels in Adults: A Systematic Review and Meta-Analysis of Clinical Trials. Complement Ther Med 2020;50:102380.
-
Governa P, Cusi MG, Borgonetti V, et al. Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells. Biomedicines 2019;7(4):73.
-
Meresta L., Meresta T. Effect of pH on bactericidal activity of propolis. Bull Veterina Inst Pulawy 1980;24:21–25.
-
Przybyłek I, Karpiński TM. Antibacterial Properties of Propolis. Molecules 2019;24(11):2047.
-
Almuhayawi MS. Propolis as a novel antibacterial agent. Saudi J Biol Sci 2020;27(11):3079–86.
-
Bretz WA, Paulino N, Nör JE, et al. The effectiveness of propolis on gingivitis: a randomized controlled trial. J Altern Complement Med 2014;20(12):943–48.
-
Pundir AJ, Vishwanath A, Pundir S, et al. One-stage Full Mouth Disinfection Using 20% Propolis Hydroalcoholic Solution: A Clinico-microbiologic Study. Contemp Clin Dent 2017;8(3):416–20.
-
Skoskiewicz-Malinowska K, Kaczmarek U, Malicka B, et al. Application of Chitosan and Propolis in Endodontic Treatment: A Review. Mini Rev Med Chem 2017;17(5):410–34.
-
Zulhendri F, Felitti R, Fearnley J, et al. The use of propolis in dentistry, oral health, and medicine: A review. J Oral Biosci 2021;63(1):23–34.
-
Martinotti S, Pellavio G, Laforenza U, et al. Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing. Molecules 2019;24(8):1544.
-
Abu-Seida AM. Effect of Propolis on Experimental Cutaneous Wound Healing in Dogs. Vet Med Int 2015;2015:672643.
-
Oryan A, Alemzadeh E, Moshiri A. Potential role of propolis in wound healing: Biological properties and therapeutic activities. Biomed Pharmacother 2018;98:469–83.
-
Kuo CC, Wang RH, Wang HH, et al. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis. Support Care Cancer 2018;26(12):4001–09.
-
Moon JH, Lee MY, Chung YJ, et al. Effect of Topical Propolis on Wound Healing Process After Tonsillectomy: Randomized Controlled Study. Clin Exp Otorhinolaryngol 2018;11(2):146–50.
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Jautová J, Zelenková H, Drotarová K, et al. Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage) : Randomized, controlled double-blind study. Wien Med Wochenschr 2019;169(7-8):193–201.
-
Al-Waili N. Mixing two different propolis samples potentiates their antimicrobial activity and wound healing property: A novel approach in wound healing and infection. Vet World 2018;11(8):1188–95.
-
Chiu HF, Han YC, Shen YC, et al. Chemopreventive and Chemotherapeutic Effect of Propolis and Its Constituents: A Mini-review. J Cancer Prev 2020;25(2):70–78.
-
Silva H, Francisco R, Saraiva A, et al. The Cardiovascular Therapeutic Potential of Propolis-A Comprehensive Review. Biology (Basel) 2021;10(1):27.
-
Afsharpour F, Javadi M, Hashemipour S, et al. Propolis supplementation improves glycemic and antioxidant status in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study. Complement Ther Med 2019;43:283–88.
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Silveira MAD, Teles F, Berretta AA, et al. Effects of Brazilian green propolis on proteinuria and renal function in patients with chronic kidney disease: a randomized, double-blind, placebo-controlled trial. BMC Nephrol 2019;20(1):140.
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Farooqui T, Farooqui AA. Beneficial effects of propolis on human health and neurological diseases. Front Biosci (Elite Ed) 2012;4:779–93.