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Keeping seasonal bugs at bay: Plants to support immunity
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Keeping seasonal bugs at bay: Plants to support immunity
Wednesday 16 April 2025, 12:30 AM
Ginger rhizome exhibits antimicrobial, anti-inflammatory and chemo-preventive activities [Image: fcafotodigital on iStock]
With winter just around the corner, pharmacist and medical herbalist Phil Rasmussen looks at plants that can support immune defences during the cold and flu season
Immunity is a subject that has received a lot more attention in recent years, with an increasing recognition of its importance as our inbuilt defence
Kia ora and welcome to Pharmacy Today Kaitiaki Rongoā O Te Wā
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References
- Lee M, Chang Y, Ahmadinejad N, et al. COVID-19 mortality is associated with pre-existing impaired innate immunity in health conditions. PeerJ 2022;10:e13227.
- Wissler A, DeWitte SN. Frailty and survival in the 1918 influenza pandemic. Proc Natl Acad of Sci USA [PNAS] 2023;120(42):e2304545120.
- Vuscan P, Kischkel B, Joosten LAB, Netea MG. Trained immunity: General and emerging concepts. Immunol Rev 2024;323(1):164–85.
- Skevaki C, Nadeau KC, Rothenberg ME, et al. Impact of climate change on immune responses and barrier defense. J Allergy Clin Immunol 2024;153(5):1194–205.
- Ozdemir C, Kucuksezer UC, Ogulur I, et al Lifestyle changes and industrialization in the development of allergic diseases. Curr Allergy Asthma Rep 2024;24(7):331–45.
- Liu S, Ding H, Song Y, et al. The potential risks posed by micro-nanoplastics to the safety of disinfected drinking water. J Hazard Mater 2023;450:131089.
- Rio P, Caldarelli M, Gasbarrini A, et al. The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease. Diseases 2024;12(6):118.
- Seastedt H, Nadeau K. Factors by which global warming worsens allergic disease. Ann Allergy Asthma Immunol 2023;131(6):694–702.
- Calder PC. Nutrition and immunity: lessons from coronavirus disease – 2019. Proc Nutr Soc 2025;84(1):8–23.
- Miles EA, Calder PC. Effects of Citrus Fruit Juices and Their Bioactive Components on Inflammation and Immunity: A Narrative Review. Front Immunol 2021;12:712608.
- Rasmussen PL. An introduced botanical paradise seen on holiday in Aotearoa New Zealand. www.herbblurb.com. January 19, 2025.
- Ayustaningwarno F, Anjani G, Ayu AM, et al. A critical review of Ginger’s (Zingiber officinale) antioxidant, anti-inflammatory, and immunomodulatory activities. Front Nutr 2024;11:1364836.
- Velayati A, Vafa MR, Sani'ee N, Darabi Z. Therapeutic effects and mechanisms of action of ginger and its bioactive components on inflammatory response, oxidative stress, the immune system, and organ failure in sepsis: a comprehensive systematic review. Nutr Rev 2024;82(12):1800–819.
- Gustafson MP, Wheatley-Guy CM, Rosenthal AC, et al. Exercise and the immune system: taking steps to improve responses to cancer immunotherapy. J Immunother Cancer 2021;9(7):e001872.
- Davison G, Kehaya C, Wyn Jones A. Nutritional and Physical Activity Interventions to Improve Immunity. Am J Lifestyle Med 2014;10(3):152–69.
- Campbell JL. COVID-19: Reducing the risk via diet and lifestyle. J Integr Med. 2023;21(1):1–16.
- Giakomidi D, Ishola A, Nus M. Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis. Front Cardiovasc Med 2025;12:1502124.
- Wang C, Bai J, Chen X, et al. Gut microbiome-based strategies for host health and disease. Crit Rev Food Sci Nutr 2024;64(19):6834–849.
- Magalhães MI, Azevedo MJ, Castro F, et al. The link between obesity and the gut microbiota and immune system in early life. Crit Rev Microbiol 2025;51(2):264–84.
- Choi W, Moniruzzaman M, Lee S, et al. Evaluation of three fish-derived probiotic bacteria replacing antibiotics on growth, immunity, gut morphology and disease resistance in juvenile olive flounder Paralichthys olivaceus fed reduced fish meal diets. Front Nutr 2025;12:1519140.
- Clavijo V and Flórez MJV. The gastrointestinal microbiome and its association with the control of pathogens in broiler chicken production: A review. Poultry Science 2018:97(3):1006–21.
- Morisette A, Kropp C, Songpadith JP, et al. Blueberry proanthocyanidins and anthocyanins improve metabolic health through a gut microbiota-dependent mechanism in diet-induced obese mice. Am J Physiol Endocrinol Metab 2020;318(6):E965–980.
- Aziz T, Hussain N, Hameed Z, Lin L. Elucidating the role of diet in maintaining gut health to reduce the risk of obesity, cardiovascular and other age-related inflammatory diseases: recent challenges and future recommendations. Gut Microbes 2024;16(1):2297864.
- Lin R, Zhi C, Su Y, et al. Effect of Echinacea on gut microbiota of immunosuppressed ducks. Front Microbiol 2023;13:1091116.
- Zhu H, Hu M, Wang D, et al. Mixed polysaccharides derived from Shiitake mushroom, Poriacocos, Ginger, and Tangerine peel enhanced protective immune responses in mice induced by inactivated influenza vaccine. Biomed Pharmacother 2020;126:110049.
- McElhaney JE, Gravenstein S, Cole SK, et al. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc 2004;52(1):13–19.
- Lee CS, Lee JH, Oh M, et al. Preventive effect of Korean red ginseng for acute respiratory illness: a randomized and double-blind clinical trial. J Korean Med Sci 2012;27(12):1472–78.
- Ojard C, Donnelly JP, Safford MM, et al. Psychosocial stress as a risk factor for sepsis: a population-based cohort study. Psychosom Med 2015;77(1):93–100.
- Lafuse WP, Wu Q, Kumar N, et al. Psychological stress creates an immune suppressive environment in the lung that increases susceptibility of aged mice to Mycobacterium tuberculosis infection. Front Cell Infect Microbiol 2022;12:990402.
- Wang S, Quan L, Ding M, et al. Depression, worry, and loneliness are associated with subsequent risk of hospitalization for COVID-19: a prospective study. Psychol Med 2023;53(9):4022–031.
- Felter HW. The Eclectic Materia Medica, Pharmacology and Therapeutics. Eclectic Medical Publications, Oregon, 1922.
- Smithsonian National Museum of Natural History. Lewis and Clark historic expedition (www.sci.edu).
- Matthias A, Banbury L, Stevenson LM, et al. Alkylamides from echinacea modulate induced immune responses in macrophages. Immunol Invest 2007;36(2):117–30.
- Park S, Lee MS, Jung S, et al. Echinacea purpurea protects against restraint stress-induced immunosuppression in BALB/c mice. J Med Food 2018;21(3):261–68.
- Chen JX, Xue HJ, Ye WC, et al. Activity of andrographolide and its derivatives against influenza virus in vivo and in vitro. Biol Pharm Bull 2009;32(8):1385–91.
- Yin X, Zhuang X, Liao M, et al. Andrographis paniculata improves growth and non-specific immunity of shrimp Litopenaeus vannamei,and protects it from Vibrio alginolyticus by reducing oxidative stress and apoptosis. Dev Comp Immunol 2023;139:104542.
- Saxena RC, Singh R, Kumar P, et al. A randomized double-blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine 2010;17(3–4):178–85.
- Hossain S, Urbi Z, Karuniawati H, et al. Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy. Life (Basel) 2021;11(4):348.
- Kulichenko LL, Kireyeva LV, Malyshkina EN, Wikman G. A randomized, controlled study of Kan Jang versus amantadine in the treatment of influenza in Volgograd. J Herb Pharmacother 2003;3(1):77–93.
- Rasmussen PL. The magic of mushrooms. Pharmacy Today 2022: May. ISSN 1170-1927, The Health Media Ltd (www.pharmacytoday.co.nz).
- Shi S, Yin L, Shen X, et al. β-Glucans from Trametes versicolor (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection. Viruses 2022;14(2):237.
- Wang L, Hou Y. Determination of trace elements in anti-influenza virus mushrooms. Biol Trace Elem Res 2011;143(3):1799–807.
- Chen BK, Chan CH, Tsao A, Wang CK. Improvement of Echinacea purpurea and Ganoderma lucidum Extracts with Cell Model on Influenza A/B Infection. Molecules 2024;29(15):3609.
- Engel AL, Sun GC, Gad E, et al. Protein-bound polysaccharide activates dendritic cells and enhances OVA-specific T cell response as vaccine adjuvant. Immunobiology 2013;218(12):1468-76.
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